Viewpoints:

Dispatches from the Frontlines of Research - edited by John W. Nelson

Igor E. Brodsky and John S. Gunn

A Bacterial Sensory System that Activates Resistance to Innate Immune Defenses: Potential Targets for Antimicrobial Therapeutics
Mol. Interv. 2005 5: 335-337. [Summary] [Full Text] [PDF]  

Benjamin C. Lin and Thomas S. Scanlan

Few Things in Life are "Free": Cellular Uptake of Steroid Hormones by an Active Transport Mechanism
Mol. Interv. 2005 5: 338-340. [Summary] [Full Text] [PDF]  

Rafael Villalobos-Molina and Maximiliano Ibarra

Increased Expression and Function of Vascular _1D-Adrenoceptors May Mediate The Prohypertensive Effects Of Angiotensin II
Mol. Interv. 2005 5: 340-342. [Summary] [Full Text] [PDF]  

R E V I E W S:

Julie M. Hall and Donald P. McDonnell

Coregulators in Nuclear Estrogen Receptor Action: From Concept to Therapeutic Targeting
Mol. Interv. 2005 5: 343-357. [Summary] [Full Text] [PDF]  

From bone density and reproductive behavior to cardiovascular and immune system effects, estrogens regulate the function of several organs and systems. Although attributed with potent and multifunctional effects, estrogen and its receptors do not work alone. Several coregulatory proteins have been found that modulate the activities of the estrogen receptors ER and ERß. By understanding how these coactivators and co-repressors work, we may be able to target these proteins for molecular intervention in sex hormone–related diseases.

Nadia F. Lamour and Charles E. Chalfant

Ceramide-1-phosphate: The "missing" link in eicosanoid biosynthesis and inflammation
Mol. Interv. 2005 5: 358-367. [Summary] [Full Text] [PDF]  

It has been over a decade since ceramide kinase (CERK) and its product, ceramide-1-phosphate (C1P), were first reported. Since its cloning, in 2002, CERK has been the subject of an explosion of publications concerning various signal transduction pathways. The roles of this previously overlooked enzyme, as well as those of its product C1P, continue to expand, and their regulatory functions in the production of eicosanoid inflammatory mediators are proving essential to fundamental signal transduction pathways. In particular, C1P is required for the activation and translocation of cPLA₂, the initial rate-limiting step of eicosanoid synthesis. The potential for inhibitors of CERK to offer a new generation of anti-inflammatory and anti-cancer therapeutics is especially deserving of further study.

Paul A. McCarron, Shane A. Olwill, Waleed M.Y. Marouf, Richard J. Buick, Brian Walker, and Christopher J. Scott

Antibody Conjugates and Therapeutic Strategies
Mol. Interv. 2005 5: 368-380. [Summary] [Full Text] [PDF]  

Chemotherapy typically involves administering very strong drugs that affect the more sensitive tumor mass but may also affect the rest of the patient's body. Antibody-based therapies have the potential to target tumors very specifically. Several different approaches to antibody conjugation are under investigation, including the addition of enzymes (that activate systemically administered prodrugs at the tumor) or radionuclides (that emit alpha particles or beta rays that kill tumor cells and minimal adjacent healthy tissue). Additionally, antibodies can be created whose two complementarity determining regions (CDRs, the highly specific antigen binding sites) recognize different antigens, further enhancing the complexity and utility of these therapeutics.

D E P A R T M E N T S:

Speaking of Pharmacology:

David B. Bylund, Laurence L. Brunton, Peter J. R. Cobbett, Adam M. Persky, and Peter C. Preusch

NIGMS-Sponsored Integrative and Organ Systems Pharmacology: Synopsis of the 2005 Experience/Anticipation of the 2006 Short Courses
Mol. Interv. 2005 5: 330-333. [Full Text] [PDF]  

Reflections:

Science in the cultural context

Rebecca Anderson

The Singular Moral Compass of Otto Krayer
Mol. Interv. 2005 5: 324-329. [Full Text] [PDF]  

Nascent Transcripts:

Nascent Transcripts
Mol. Interv. 2005 5: 334. [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

John W. Nelson and John S. Lazo

Gift Books by Gifted Authors
Mol. Interv. 2005 5: 381-383. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web–edited by Rick Neubig and David Roman
Mol. Interv. 2005 5: 384. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2005 5: 388. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many summaries, check the boxes to the left of the titles you want, and click the 'Get All Checked Summary(s)' button. To see one summary at a time, click its [Summary] link.