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Immunofluorescent detection of choline transporters (CHTs, red) and serotonin transporters (SERTs, green) in the mouse trigeminal nucleus. CHT immunoreactivity is present in motor neuron cell bodies as well as in the large cholinergic presynaptic C-boutons that contact them, whereas the anti-SERT antibody selectively labels serotoninergic fibers and their presynaptic terminals. This example illustrates the specificity of CHT and SERT as markers of cholinergic and serotoninergic neurons, respectively. From a functional point of view, the presynaptic localization of CHT allows the recapture of choline generated from the acetylcholinesterase-mediated hydrolysis of acetylcholine. Meanwhile, SERT terminates the actions of synaptically released serotonin by recapturing it back into the presynaptic terminal. Photo courtesy of Valentina Savchenko, Vanderbilt University. See the Review Article by Ferguson et al., on pages 22Ð37.