About the Cover
The important roles of the caveolins, proteins that define the small invaginations of cell membrane known as caveolae, are being elucidated through the generation of knockout mice. On the cover of this issue are two Matrigel plugs (complex mixtures of extracellular matrix components) that had been implanted into mice along with administration of an angiogenic agent. In the foreground is a plug excised from a wild-type mouse; the background plug comes from a knockout mouse that lacks caveolin-1. The importance of caveolin-1 on blood vessel infiltration and density is apparent from the less vascularized plug from the knockout animal. The roles of the caveolins in angiogenesis and in multiple disease states is discussed in the review article from Hnasko and Lisanti on pages 445-464. [Reprinted from Am. J. Pathol. 162, 2059-2068 with permission from The American Society for Investigative Pathology.]
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Copyright © 2004 by the American Society for Pharmacology and Experimental Therapeutics.
