Viewpoints:

Dispatches from the Frontlines of Research - edited by John W. Nelson

Zigang Dong and Ann M. Bode

Dialogue Between ERKs and JNKs: Friendly or Antagonistic?
Mol. Interv. 2003 3: 306-308. [Summary] [Full Text] [PDF]  

R E V I E W S:

Roy Fleischmann and Dave Shealy

Developing a New Generation of TNF Antagonists for the Treatment of Rheumatoid Arthritis
Mol. Interv. 2003 3: 310-318. [Summary] [Full Text] [PDF]  

Within the last few years, a slew of engineered antibodies have entered into clinical trials for the treatment of a wide variety of diseases, from cancer to psoriasis. FDA-approved monoclonal antibody-based drugs for the treatment of rheumatoid arthritis exemplify the approaches to the engineering of antibodies that are being pursued by an ever-growing number of drug companies.

Elaine Sanders-Bush, Hugh Fentress, and Lisa Hazelwood

Serotonin 5-HT₂ Receptors: Molecular and Genomic Diversity
Mol. Interv. 2003 3: 319-330. [Summary] [Full Text] [PDF]  

Understanding the association between propensity for disease and the specific array of receptor subtypes roduced in any individual remains an important goal within the context of many different hormone, neurotransmitter, and signal transduction studies. A focus on the two serotonin receptor subtypes 5-HT2A and 5-HT2C reveals the richness of biological mechanisms that can give rise to receptor diversity, regulate receptor subtype diversity over time, and contribute to the individual's responses to signals in health and disease.

Colin J. Henderson and C. Roland Wolf

Transgenic Analysis of Human Drug–Metabolizing Enzymes: Preclinical Drug Development and Toxicology
Mol. Interv. 2003 3: 331-343. [Summary] [Full Text] [PDF]  

Humans have evolved a variety of enzymes, including the cytochromes P450, to protect themselves against chemical challenges from the environment. These enzyme systems frequently represent a barrier to the in vivo efficacy of administered drugs, and researchers who wish to develop a new drug must therefore be able to anticipate how the human drug-metabolizing machinery may act to thwart their best efforts. Because animal models do not always reflect drug metabolism as it occurs in humans, mice engineered through transgenic technologies to more accurately reflect human metabolism are becoming essential to modern experimental therapeutics.

D E P A R T M E N T S:

Beyond the Bench:

Representations of pharmacology and science in the media

Christie Carrico

A Pox upon U.S. (1774–1882)
Mol. Interv. 2003 3: 344-345. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web—compiled by John W. Nelson
Mol. Interv. 2003 3: 346. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2003 3: 352. [Full Text] [PDF]  

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