Viewpoints:

Dispatches from the Frontlines of Research - edited by John W. Nelson

Gerald W. Zamponi and Terrance P. Snutch

Modulating Modulation: Crosstalk Between Regulatory Pathways of Presynaptic Calcium Channels
Mol. Interv. 2002 2: 476-478. [Summary] [Full Text] [PDF]  

François Mach

Toward a Role for Statins in Immunomodulation
Mol. Interv. 2002 2: 478-480. [Summary] [Full Text] [PDF]  

Sheila A. Stewart

Multiple Levels of Telomerase Regulation
Mol. Interv. 2002 2: 481-483. [Summary] [Full Text] [PDF]  

R E V I E W S:

Íbrahim Halil Kavakli and Aziz Sancar

Circadian Photoreception in Humans and Mice
Mol. Interv. 2002 2: 484-492. [Summary] [Full Text] [PDF]  

Circadian rhythms allow organisms to optimize particular behaviors with regard to the time of day. The molecular mechanisms that account for the nightlife of mice, and the working day of humans, rest on light-dependent oscillations in the expression of specific proteins. Chief among these are the cryptochromes, proteins that absorb blue light and appear to act as photoreceptors in the circadian rhythms of humans and mice, as well as in plants, where cryptochromes were first discovered. Research into the brain’s clockwork has recently received new impetus, based on an appreciation that the circadian rhythm is germane not only to disturbances of mood and sleep cycles, but also to pharmacological interventions into disease states such as cancer.

Hiroshi Hosoda, Masayasu Kojima, and Kenji Kangawa

Ghrelin and the Regulation of Food Intake and Energy Balance
Mol. Interv. 2002 2: 494-503. [Summary] [Full Text] [PDF]  

By age thirty-five, one in four Americans is obese. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is secreted by the stomach and stimulates food intake. Ghrelin accomplishes this by facilitating growth hormone secretion and by transducing signals to hypothalamic regulatory nuclei that control energy homeostasis. Hosoda and colleagues review what is known about the molecular mechanisms by which ghrelin regulates hunger, satiety, and obesity. Understanding how ghrelin regulates the sensation or perception of hunger may yield promising future therapies for appetite control and overcoming anorexic behavior.

D E P A R T M E N T S:

Erratum:

erratum: The "Heartbreak" of Older Age
Mol. Interv. 2002 2: 503. [Full Text] [PDF]  

Reflections:

Science in the cultural context

James E. Barrett

The Emergence of Behavioral Pharmacology
Mol. Interv. 2002 2: 470-475. [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Christie Carrico

Overhead Is Murder
Mol. Interv. 2002 2: 504. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web—edited by Rick Neubig
Mol. Interv. 2002 2: 505. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2002 2: 512. [Full Text] [PDF]  

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