Viewpoints:

Dispatches from the Frontlines of Research - edited by John W. Nelson

Rene Vandenboom and Joseph M. Metzger

A "Wringing" Endorsement for Myosin Phosphorylation in the Heart
Mol. Interv. 2002 2: 422-424. [Summary] [Full Text] [PDF]  

Bethany J. Holycross and M. Judith Radin

Cytokines in Heart Failure: Potential Interactions with Angiotensin II and Leptin
Mol. Interv. 2002 2: 424-427. [Summary] [Full Text] [PDF]  

Philip L. Cohen

Autoimmunity and Lymphoproliferation: Two Genes are Worse than One
Mol. Interv. 2002 2: 427-430. [Summary] [Full Text] [PDF]  

R E V I E W S:

Edward G. Lakatta and Steven J. Sollott

The "Heartbreak" of Older Age
Mol. Interv. 2002 2: 431-446. [Summary] [Full Text] [PDF]  

As the heart ages, it undergoes certain adaptations, some beneficial and compensatory and some not, in response to changes in arterial plasticity. Simple interventions including exercise and dietary changes, such as the ingestion of specific polyunsaturated fatty acids, may provide lasting cardiovascular benefits. Better understanding of the physiological changes that occur in the aging heart, from the molecular to the whole organ, may lead to more effective future treatments and preventive medicine.

William T. Gerthoffer and Cherie A. Singer

Secretory Functions of Smooth Muscle: Cytokines and Growth Factors
Mol. Interv. 2002 2: 447-456. [Summary] [Full Text] [PDF]  

Smooth muscle has long been recognized for its role in controlling the contractility of hollow organs, including the vasculature, gastrointestinal tract, airways, and uterus. The dynamic functions of smooth muscle cells in the genesis and remodeling of these organs and organ systems, have, however, gone largely unappreciated. Particularly during inflammation, smooth muscle cells synthesize a variety of signaling proteins that can contribute to both disease and its amelioration.

D E P A R T M E N T S:

Erratum:

Jason M. Haugh

erratum: Localization of Receptor-Mediated Signal Transduction Pathways: The Inside Story
Mol. Interv. 2002 2: 430. [Full Text] [PDF]  

Speaking of Pharmacology:

Harry Smith

An MI Questionnaire
Mol. Interv. 2002 2: 416. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

In the Service of Pharmacology
Mol. Interv. 2002 2: 418-421. [Summary] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Christine K. Carrico

Formula 51
Mol. Interv. 2002 2: 458. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web—edited by Rick Neubig
Mol. Interv. 2002 2: 457. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2002 2: 464. [Full Text] [PDF]  

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