Viewpoints:

Dispatches from the Frontlines of Research - edited by John W. Nelson

Zhixiang Wang and Michael F. Moran

Phospholipase C–1: A Phospholipase and Guanine Nucleotide Exchange Factor
Mol. Interv. 2002 2: 352-355. [Summary] [Full Text] [PDF]  

Stephen C. Bunnell

Determining the Destiny of NF- B after TCR Ligation: It’s CARMA1
Mol. Interv. 2002 2: 356-360. [Summary] [Full Text] [PDF]  

Guojun Cheng, Otabek Imamov, Yoko Omoto, Margaret Warner, and Jan-Åke Gustafsson

What is the Value of Measuring MTA-1s in Breast Cancer?
Mol. Interv. 2002 2: 360-362. [Summary] [Full Text] [PDF]  

R E V I E W S:

K.R. Bales, J.C. Dodart, R.B. DeMattos, D.M. Holtzman, and S.M. Paul

Apolipoprotein E, Amyloid, and Alzheimer Disease
Mol. Interv. 2002 2: 363-375. [Summary] [Full Text] [PDF]  

Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein E (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.

Edwin J. Weeber, Jonathan M. Levenson, and J. David Sweatt

Molecular Genetics of Human Cognition
Mol. Interv. 2002 2: 376-391. [Summary] [Full Text] [PDF]  

Our understanding of the molecular underpinnings of human cognition has been greatly aided by the convergent synergy of clinical, genetic, and signaling research. By identifying the mutated genes that give rise to syndromes of mental retardation or cognitive defects in patients, and by placing the associated gene products within signaling networks, researchers are piecing together how learning occurs and how memories are formed and sustained.

Donald D. Price

Central Neural Mechanisms that Interrelate Sensory and Affective Dimensions of Pain
Mol. Interv. 2002 2: 392-403. [Summary] [Full Text] [PDF]  

The perception of pain is highly complex, and requires neural integration from a variety of routes. Spinal pathways to the amygdala, hypothalamus, reticular formation, medial thalamic nuclei, and limbic cortical structures transmit information involved in arousal, bodily regulation, and emotional responses. Other, albeit indirect, pathways can carry signals to these same structures, for example, from spinal pathways to somatosensory thalamic and cortical areas, and from these areas to cortical limbic structures. Indirect cortico-limbic pathways integrate nociception with information about the status of the body and self to provide cognitive mediation of pain affect. Both direct and indirect routes must culminate in the prioritization of emotions and responses to pain.

D E P A R T M E N T S:

Reflections:

Science in the cultural context

Nathan Greenslit

Pharmaceutical Branding: Identity, Individuality, and Illness
Mol. Interv. 2002 2: 342-345. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

Research as an Art Form
Mol. Interv. 2002 2: 346-351. [Summary] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

John Nelson

A Fire in the Mind
Mol. Interv. 2002 2: 404-405. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web—edited by Rick Neubig
Mol. Interv. 2002 2: 411. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2002 2: 412. [Full Text] [PDF]  

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