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The expression of green fluorescent protein (GFP) is greatly decreased in leaves from Nicotiana benthamiana through RNA-interference­ (RNAi)­mediated silencing of GFP RNA (top leaf). GFP accumulates (green and yellow areas, bottom leaf) after RNAi-dependent silencing is suppressed by the expression of the B2 protein from flock house virus. B2 can also inhibit RNA silencing in cultured Drosophila melanogaster cells, indicating that a highly conserved RNA silencing pathway exists in the plant and animal kingdoms. [Image: Shou-Wei Ding]. Inset: The expression of nuclear lamin (in red) is silenced in HeLa cells transfected with lamin small interfering-RNA (siRNA) duplexes (top image), but not with control siRNA duplexes (bottom image). See the Review by Tuschl and Borkhardt on pages 158­167.