Viewpoints:

Dispatches from the Frontlines of Research - edited by John W. Nelson

Daniel Goodenough and Friso Postma

Pulse-Chase in the Light Microscope
Mol. Interv. 2002 2: 132-134. [Summary] [Full Text] [PDF]  

Selena E. Bartlett and Jennifer L. Whistler

The Near-Death Experience of Delta Opioid Receptors Leads to New Drug Targets
Mol. Interv. 2002 2: 134-136. [Summary] [Full Text] [PDF]  

Peter J. Dempsey, Kyle Garton, and Elaine W. Raines

Emerging Roles of TACE as a Key Protease in ErbB Ligand Shedding
Mol. Interv. 2002 2: 136-141. [Summary] [Full Text] [PDF]  

Thomas T. Su, Beichu Guo, and David J. Rawlings

Emerging Roles for PKC Isoforms in Immune Cell Function
Mol. Interv. 2002 2: 141-144. [Summary] [Full Text] [PDF]  

R E V I E W S:

Marina E. Wolf

Addiction: Making the Connection Between Behavioral Changes and Neuronal Plasticity in Specific Pathways
Mol. Interv. 2002 2: 146-157. [Summary] [Full Text] [PDF]  

Drugs of abuse affect the mechanisms by which the brain processes learning and memory events. Chronically abused substances wreak havoc with the ability of neurons to undergo normal long-term potentiation (LTP) and long-term depression (LTD), resulting in maladaptive learning and in the reinforcement of craving and drug-seeking behavior. Changes in neuronal plasticity are now being successfully mapped to account for drug-related behavioral responses.

Thomas Tuschl and Arndt Borkhardt

Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy
Mol. Interv. 2002 2: 158-167. [Summary] [Full Text] [PDF]  

Like a distant thunderclap growing louder and furiously rolling closer to an observer, the research field that encompasses RNA silencing (RNA interference or RNAi) has recently exploded with examples of RNAi-mediated regulation in cultured mammalian cells. Now, RNAi is being exploited to validate protein targets for pharmaceutical intervention, and might prove useful in correcting genetic abnormalities or metabolically based diseases through gene therapy.

Roger K. Sunahara and Ron Taussig

Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling
Mol. Interv. 2002 2: 168-184. [Summary] [Full Text] [PDF]  

Great advances have been made recently in elucidating the structures of adenylyl cyclases (ACs), and in discovering many of the proteins and small molecules that affect their catalytic activity. Further discovery and refinement of existing observations will lead to better, more intelligent design of pharmacological therapeutics that can correct abnormal AC activity in disease states.

D E P A R T M E N T S:

Speaking of Pharmacology:

Where in the World Is Pharmacology Headed?: (And Where in the World Is It Coming From?)
Mol. Interv. 2002 2: 122-123. [Full Text] [PDF]  

Reflections:

Science in the cultural context

Joseph Dumit

Drugs for Life
Mol. Interv. 2002 2: 124-127. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

An Uncommon Scientist with a Lot of Common Sense
Mol. Interv. 2002 2: 128-131. [Summary] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

John W. Nelson

Color Me With Good Fortune
Mol. Interv. 2002 2: 186-187. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web: —edited by Rick Neubig
Mol. Interv. 2002 2: 188. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2002 2: 192. [Full Text] [PDF]  

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