R E V I E W S:

Yuan Zhang and David J. Mangelsdorf

LuXuRies of Lipid Homeostasis: The Unity of Nuclear Hormone Receptors, Transcription Regulation, and Cholesterol Sensing
Mol. Interv. 2002 2: 78-87. [Summary] [Full Text] [PDF]  

The nuclear transcription factors LXR{alpha} and LXRß help to control circulating levels of fatty acids and cholesterol by stimulating the expression of genes associated with lipid and sterol modification, storage, and removal. Knowing how the expression and the activity of these transcription factors are regulated may aid in the development of treatments for disorders of lipid storage and elimination.

Randall J. Kimple, Francis S. Willard, and David P. Siderovski

The GoLoco Motif: Heralding a New Tango Between G Protein Signaling and Cell Division
Mol. Interv. 2002 2: 88-100. [Summary] [Full Text] [PDF]  

Although the G{alpha} and the Gß{gamma} subunits of heterotrimeric G proteins can effect different signaling processes in cells, the mechanisms that govern their different signaling outcomes have been underappreciated. GoLoco motif-containing proteins bind specifically to G{alpha} loaded with GDP, and hinder Gß{gamma} from re-associating to G{alpha}. Thus, Gß{gamma}-dependent signals may be sustained. Additionally, "GoLoco proteins" may have effector functions themselves, particularly in the regulation of cell division.

Stefanie S. Jeffrey, Michael J. Fero, Anne-Lise Børresen-Dale, and David Botstein

Expression Array Technology in the Diagnosis and Treatment of Breast Cancer
Mol. Interv. 2002 2: 101-109. [Summary] [Full Text] [PDF]  

Just a few years ago, the amazing thing about microarrays was that they worked; today, microarrays astound with the detail of biomedical information they can provide. Breast cancer research is a prime example, where microarrays are helping to establish etiology, diagnosis, and treatment strategies.

D E P A R T M E N T S:

Speaking of Pharmacology:

Harry Smith

MOLECULAR INTERVENTIONS Volume 2: This Time It's Personal
Mol. Interv. 2002 2: 71. [Full Text] [PDF]  

Reflections:

Science in the cultural context

Andrew Lakoff

The Mousetrap: Managing the Placebo Effect in Antidepressant Trials
Mol. Interv. 2002 2: 72-76. [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Christine K. Carrico

Testing One's Mettle: Reminiscences of Childhood and Rediscovering the Chemistry Wheel
Mol. Interv. 2002 2: 110-111. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web
Mol. Interv. 2002 2: 77. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2002 2: 116. [Full Text] [PDF]  

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