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Anti-Inflammatory Therapies through the Millennia

The pain-relieving properties of willow bark have been known since Hippocrates, and salicylate, a natural product within the bark, and its acetylated congener aspirin, helped launch the modern pharmaceutical industry. The targeting of cyclooxygenase by acetylsalicylate has been appreciated for decades, but new insights into the role of nuclear factor κB in anti-inflammatory strategies—both old and new—may herald novel therapies in a wide range of diseases. Read the Review by D'Acquisto et al. on pages 22­35 for details.