R E V I E W S:

Fulvio D'Acquisto, Michael J. May, and Sankar Ghosh

Inhibition of Nuclear Factor Kappa B (NF-B):: An Emerging Theme in Anti-Inflammatory Therapies
Mol. Interv. 2002 2: 22-35. [Summary] [Full Text] [PDF]  

Nuclear factor {kappa}B (NF-{kappa}B) regulates the transcription of a number of proinflammatory mediators. NF-{kappa}B turns out to be an important target of traditional anti-inflammatory agents (like aspirin), and has been singled out for targeting by a new generation of drugs.

Xiao-yu R. Song, Theodore J. Torphy, Don E. Griswold, and David Shealy

Coming of Age:Anti–Cytokine Therapies
Mol. Interv. 2002 2: 36-46. [Summary] [Full Text] [PDF]  

Immune disorders that are supported by the action of cytokines are now giving way to novel therapeutics. The potential of biopharmaceuticals is transitioning into reality within the context of many diseases.

E. Costa, Y. Chen, J. Davis, E. Dong, J.S. Noh, L. Tremolizzo, M. Veldic, D.R. Grayson, and A. Guidotti

REELIN and Schizophrenia:: A Disease at the Interface of the Genome and the Epigenome
Mol. Interv. 2002 2: 47-57. [Summary] [Full Text] [PDF]  

Silencing of the Reelin gene may contribute to the etiology of schizophrenia. Investigations of Reelin and of the epigenetic mechanisms that regulate neurodevelopmental genes may provide approaches to treating psychiatric illness.

D E P A R T M E N T S:

Speaking of Pharmacology:

Barry A. Berkowitz and George Sachs

Life Cycle of A Block Buster Drug: Discovery and Development of Omeprazole (Prilosec^TM)
Mol. Interv. 2002 2: 6-11. [Summary] [Full Text] [PDF]  

Reflections:

Science in the cultural context

Jennifer R. Fishman

Sex, Drugs, and Clinical Research
Mol. Interv. 2002 2: 12-16. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

Science for the Common Good
Mol. Interv. 2002 2: 17-21. [Summary] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Christine K. Carrico

The Opium (and Tobacco and Caffeine) of the Masses
Mol. Interv. 2002 2: 59. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2002 2: 64. [Full Text] [PDF]  

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