R E V I E W S:

Yue-Ming Li

-Secretase: A Catalyst of Alzheimer Disease and Signal Transduction
Mol. Interv. 2001 1: 198-207. [Abstract] [Full Text] [PDF]  

The secretases, proteolytic activities that contribute to the molecular etiology of Alzheimer disease, are being intensively investigated as possible therapeutic targets. The investigation of these proteases is also yielding new insights into basic mechanisms of signal transduction.

S. J. Enna

A GABA_B Mystery: The Search for Pharmacologically Distinct GABA_B Receptors
Mol. Interv. 2001 1: 208-218. [Abstract] [Full Text] [PDF]  

GABAB receptors are distributed widely throughout the central nervous system, and research into their biogenesis and regulation has refined our understanding of G protein-coupled receptors. The sleuthing skills of pharmacologists nevertheless continue to be challenged by this important group of receptors.

Avtar Roopra, Yunfei Huang, and Raymond Dingledine

Neurological Disease: Listening to Gene Silencers
Mol. Interv. 2001 1: 219-228. [Abstract] [Full Text] [PDF]  

Studies of neuronal gene regulation in health and disease are defining new levels of versatility in regard to the protein factors and gene elements that govern transcription. As research into the regulatory protein NRSF demonstrates, the molecular players of the gene regulatory stage can receive and change their roles according to cellular context.

D E P A R T M E N T S:

Speaking of Pharmacology:

Editorial

Kelvin Gee

Academic Entrepreneur—An Oxymoron?
Mol. Interv. 2001 1: 186-188. [Full Text] [PDF]  

Reflections:

Science in the cultural context

Ryan J. Huxtable and Stephan K. W. Schwarz

The Isolation of Morphine—First Principles in Science and Ethics
Mol. Interv. 2001 1: 189-191. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

Floyd Bloom: Neuroscience was not even a word
Mol. Interv. 2001 1: 192-197. [Abstract] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Christine K. Carrico

For Killers, Conjurers, and Curers
Mol. Interv. 2001 1: 230-231. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web—edited by Rick Neubig
Mol. Interv. 2001 1: 232. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2001 1: 235. [Full Text] [PDF]  

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