Pharmacology: It's only natural.

The pharmacological regulation of specific protein-encoding genes is one of the promises of modern biomedicine. On pages 117-125, Scotto and Johnson discuss research that is bringing this promise closer to fruition in the case of MDR1, a gene that is crucial to clinical manifestations of multidrug resistance. The cover shows the sea squirt Ecteinascidia turbinata, the natural source of a therapeutic candidate that targets the transcription of MDR1. (Image courtesy of PharmaMar, Inc.)