R E V I E W S:

James W. Putney, Jr.

Pharmacology of Capacitative Calcium Entry
Mol. Interv. 2001 1: 84-94. [Abstract] [Full Text] [PDF]  

Cells have multiple reservoirs of Ca²⁺ ions to draw from in response to diverse and often competing stimuli. The mechanisms by which cells coordinate cytosolic Ca²⁺ flux are now being probed as pharmacological targets.

Geoffrey W. Abbott and Steve A. N. Goldstein

Potassium Channel Subunits: The MiRP Family
Mol. Interv. 2001 1: 95-107. [Abstract] [Full Text] [PDF]  

Voltage-gated potassium channels are essential to the normal physiology of numerous cells and organs. The discovery of novel protein components of these channels has important implications for diverse pathological conditions.

Kenneth P. Minneman

Splice Variants of GPCRs
Mol. Interv. 2001 1: 108-116. [Abstract] [Full Text] [PDF] Expanded Tables  

The existence of splice variants of human G protein-coupled receptors is in itself an intriguing bit of biology. Even more fascinating are the subtle but significant ways that certain splice variants may affect protein-protein interactions involved in signaling.

Kathleen W. Scotto and Robert A. Johnson

Transcription of MDR1: A Therapeutic Target
Mol. Interv. 2001 1: 117-125. [Abstract] [Full Text] [PDF]  

Multidrug resistance can be an important clinical hurdle to the effective treatment of tumors. Pharmacological approaches to multidrug resistance are benefiting from, as well as contributing to, new insights into mechanisms of specific gene regulation.

D E P A R T M E N T S:

Open Channels:

Letters from Our Readers

Bryan Cox and Dr. Arnie Schwartz

Letters to the editor • Dear MI: • MI responds: • Dear Integrative Pharmacologist:
Mol. Interv. 2001 1: 74. [Full Text] [PDF]  

Reflections:

Science in the cultural context

Ryan J. Huxtable

The Erroneous Pharmacology of a Cat
Mol. Interv. 2001 1: 75-77. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

Perry B. Molinoff

Common to Both Academia and Industry: The Challenge of Discovery
Mol. Interv. 2001 1: 78-83. [Abstract] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Bernard J. Baars

Mind, Brain, and the Limits of Science: What Makes Us Think? Jean-Pierre Changeux and Paul Ricoeur. New Jersey: Princeton University; 2000. 336 pages. $29.95. ISBN: 0691009406
Mol. Interv. 2001 1: 126-127. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web—edited by Rick Neubig
Mol. Interv. 2001 1: 128-130. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2001 1: 131. [Full Text] [PDF]  

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