R E V I E W S:

Edith G. McGeer and Patrick L. McGeer

Innate Immunity in Alzheimer's Disease: A Model for Local Inflammatory Reactions
Mol. Interv. 2001 1: 22-29. [Abstract] [Full Text] [PDF]  

Inflammation was characterized as a localized process over a century ago. Still, as McGeer and McGeer demonstrate, local inflammatory reactions remain decisive factors in some of the most important diseases of our time.

Issam A. Mardini and Garret A. FitzGerald

Selective Inhibitors of Cyclooxygenase-2: A Growing Class of Anti-Inflammatory Drugs
Mol. Interv. 2001 1: 30-38. [Abstract] [Full Text] [PDF]  

Predicted to become among the greatest pharmaceutical blockbusters, two so-called coxibs are now widely prescribed. Mardini and FitzGerald discuss the clinical ramifications of the widespread use of these drugs.

R.L. Juliano, A. Astriab-Fisher, and D. Falke

Macromolecular Therapeutics: Emerging Strategies for Drug Discovery in the Postgenome Era
Mol. Interv. 2001 1: 40-53. [Abstract] [Full Text] [PDF]  

New technologies in chemistry and genomics have renewed the therapeutic appeal of "molecular" biology. Juliano et al. consider the novel macromolecular strategies within a pharmacological context.

Harvey B. Pollard, Ofer Eidelman, Kenneth A. Jacobson, and Meera Srivastava

Pharmacogenomics of Cystic Fibrosis
Mol. Interv. 2001 1: 54-63. [Abstract] [Full Text] [PDF]  

In the pregenomics era, the molecular basis of cystic fibrosis was a revolutionary discovery. Today, as Pollard et al. show, pharmacogenomics promises to bring genome-wide perspectives to many diseases, including cystic fibrosis.

D E P A R T M E N T S:

Speaking of Pharmacology:

Editorial

Sue P. Duckles

Dial M for Molecular
Mol. Interv. 2001 1: 6-7. [Full Text] [PDF]  

Reflections:

Science in the cultural context

Ryan J. Huxtable

Beethoven: A Life of Sound and Silence
Mol. Interv. 2001 1: 8-12. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

Alfred Goodman Gilman

Please Check EGO at Door
Mol. Interv. 2001 1: 14-21. [Abstract] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Christine K. Carrico

In Quest of Pharmacology: Medicine Quest. Mark J. Plotkin. New York: Viking; 2000. 304 pages. $22.95. ISBN: 0670869376
Mol. Interv. 2001 1: 64-65. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Mol. Interv. 2001 1: 66. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2001 1: 68. [Full Text] [PDF]  

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