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Reviews

Current Issue: April 1, 2008; 8 (2) [Table of Contents]

Stephen R. Bloom, Francis P. Kuhajda, Ismail Laher, Xavier Pi-Sunyer, Gabriele V. Ronnett, Tricia M.M. Tan, and David S. Weigle

The Obesity Epidemic: Pharmacological Challenges
MI 2008 8: 82 10.1124/mi.8.2.6 [Summary] [Full Text] [PDF]  
Published April 1, 2008

P. Jeffrey Conn, Carol Tamminga, Darryle D. Schoepp, and Craig Lindsley

Schizophrenia: Moving Beyond Monoamine Antagonists
MI 2008 8: 99 10.1124/mi.8.2.7 [Summary] [Full Text] [PDF]  
Published April 1, 2008

Past Issues:

Brooke B. Ancrile, Kevin M. O’Hayer, and Christopher M. Counter

Oncogenic Ras–Induced Expression of Cytokines: A New Target of Anti-Cancer Therapeutics
MI 2008 8: 22 10.1124/mi.8.1.6 [Summary] [Full Text] [PDF]  
Published February 1, 2008

Karsten Gronert

Lipid Autacoids in Inflammation and Injury Responses: A Matter of Privilege
MI 2008 8: 28 10.1124/mi.8.1.7 [Summary] [Full Text] [PDF]  
Published February 1, 2008

Robert A. Newman, Peiying Yang, Alison D. Pawlus, and Keith I. Block

Cardiac Glycosides as Novel Cancer Therapeutic Agents
MI 2008 8: 36 10.1124/mi.8.1.8 [Summary] [Full Text] [PDF]  
Published February 1, 2008

Danyelle M. Townsend

S-Glutathionylation: Indicator of Cell Stress and Regulator of the Unfolded Protein Response
MI 2007 7: 313 10.1124/mi.7.6.7 [Summary] [Full Text] [PDF]  
Published December 1, 2007

Robert Kinders, Ralph E. Parchment, Jay Ji, Shivaani Kummar, Anthony J. Murgo, Martin Gutierrez, Jerry Collins, Larry Rubinstein, Oxana Pickeral, Seth M. Steinberg, Sherry Yang, Melinda Hollingshead, Alice Chen, Lee Helman, Robert Wiltrout, Mel Simpson, Joseph E. Tomaszewski, and James H. Doroshow

Phase 0 Clinical Trials in Cancer Drug Development: From FDA Guidance to Clinical Practice
MI 2007 7: 325 10.1124/mi.7.6.9 [Summary] [Full Text] [PDF]  
Published December 1, 2007

Baldomero M. Olivera and Russell W. Teichert

Diversity of the Neurotoxic Conus Peptides: A Model for Concerted Pharmacological Discovery
MI 2007 7: 251 10.1124/mi.7.5.7 [Summary] [Full Text] [PDF]  
Published October 1, 2007

Guy R Seabrook, William J. Ray, Mark Shearman, and Michael Hutton

BEYOND AMYLOID: The Next Generation of Alzheimer’s Disease Therapeutics
MI 2007 7: 261 10.1124/mi.7.5.8 [Summary] [Full Text] [PDF]  
Published October 1, 2007

Sunil Laxman and Joseph A. Beavo

Cyclic Nucleotide Signaling Mechanisms in Trypanosomes: Possible Targets for Therapeutic Agents
MI 2007 7: 203 10.1124/mi.7.4.7 [Summary] [Full Text] [PDF]  
Published August 1, 2007

Lawrence D. Mayer and Andrew S. Janoff

Optimizing Combination Chemotherapy by Controlling Drug Ratios
MI 2007 7: 216 10.1124/mi.7.4.8 [Summary] [Full Text] [PDF]  
Published August 1, 2007

Louis-Eric Trudeau and Rafael Gutiérrez

On Cotransmission & Neurotransmitter Phenotype Plasticity
MI 2007 7: 138 10.1124/mi.7.3.5 [Summary] [Full Text] [PDF]  
Published June 1, 2007

Yumin Chen, Paiboon Jungsuwadee, Mary Vore, D. Allan Butterfield, and Daret K. St. Clair

Collateral Damage in Cancer Chemotherapy: Oxidative Stress in Nontargeted Tissues
MI 2007 7: 147 10.1124/mi.7.3.6 [Summary] [Full Text] [PDF]  
Published June 1, 2007

Manuel Miranda and Alexander Sorkin

Regulation of Receptors and Transporters by Ubiquitination: New Insights into Surprisingly Similar Mechanisms
MI 2007 7: 157 10.1124/mi.7.3.7 [Summary] [Full Text] [PDF]  
Published June 1, 2007

Karl-Erik Andersson and George J. Christ

REGENERATIVE PHARMACOLOGY: THE FUTURE IS NOW
MI 2007 7: 79 10.1124/mi.7.2.8 [Summary] [Full Text] [PDF]  
Published April 1, 2007

R. Kyle Palmer

The Pharmacology and Signaling of Bitter, Sweet, and Umami Taste Sensing
MI 2007 7: 87 10.1124/mi.7.2.9 [Summary] [Full Text] [PDF]  
Published April 1, 2007

Vanja Petrovic, Shirley Teng, and Micheline Piquette-Miller

REGULATION OF DRUG TRANSPORTERS: DURING INFECTION AND INFLAMMATION
MI 2007 7: 99 10.1124/mi.7.2.10 [Summary] [Full Text] [PDF]  
Published April 1, 2007

Holger Römpler, Claudia Stäubert, Doreen Thor, Angela Schulz, Michael Hofreiter, and Torsten Schöneberg

G Protein-Coupled Time Travel: Evolutionary Aspects of GPCR Research
MI 2007 7: 17 10.1124/mi.7.1.5 [Summary] [Full Text] [PDF]  
Published February 1, 2007

Grant D. Nicol and Michael R. Vasko

Unraveling the Story of NGF-mediated Sensitization of Nociceptive Sensory Neurons: ON or OFF the Trks?
MI 2007 7: 26 10.1124/mi.7.1.6 [Summary] [Full Text] [PDF] [Erratum]  
Published February 1, 2007

Linda K. Friedman

CALCIUM: A Role for Neuroprotection and Sustained Adaptation
MI 2006 6: 315 10.1124/mi.6.6.5 [Summary] [Full Text] [PDF]  
Published December 1, 2006

Qun-Yong Zhou

The Prokineticins: A NOVEL PAIR OF REGULATORY PEPTIDES
MI 2006 6: 330 10.1124/mi.6.6.6 [Summary] [Full Text] [PDF]  
Published December 1, 2006

Peter W. Kalivas, Jamie Peters, and Lori Knackstedt

Animal Models and Brain Circuits in Drug Addiction
MI 2006 6: 339 10.1124/mi.6.6.7 [Summary] [Full Text] [PDF]  
Published December 1, 2006

Timothy A. Vortherms and Bryan L. Roth

Salvinorin A: From Natural Product to Human Therapeutics
MI 2006 6: 257 10.1124/mi.6.5.7 [Summary] [Full Text] [PDF]  
Published October 1, 2006

Philip J. Hajduk

SAR by NMR: Putting the Pieces Together
MI 2006 6: 266 10.1124/mi.6.5.8 [Summary] [Full Text] [PDF]  
Published October 1, 2006

Jack Bergman and Carol A. Paronis

Measuring the Reinforcing Strength of Abused Drugs
MI 2006 6: 273 10.1124/mi.6.5.9 [Summary] [Full Text] [PDF]  
Published October 1, 2006

Ravindra Rajakariar, Muhammad M. Yaqoob, and Derek W. Gilroy

COX-2 in Inflammation and Resolution
MI 2006 6: 199 10.1124/mi.6.4.6 [Summary] [Full Text] [PDF]  
Published August 1, 2006

Elizabeth Jonas

BCL-xL Regulates Synaptic Plasticity
MI 2006 6: 208 10.1124/mi.6.4.7 [Summary] [Full Text] [PDF]  
Published August 1, 2006

Allan E. Rettie and Guoying Tai

The Pharmocogenomics of Warfarin: Closing in on Personalized Medicine
MI 2006 6: 223 10.1124/mi.6.4.8 [Summary] [Full Text] [PDF]  
Published August 1, 2006

Michael Dean

CANCER STEM CELLS: Redefining the Paradigm of Cancer Treatment Strategies
MI 2006 6: 140 10.1124/mi.6.3.5 [Summary] [Full Text] [PDF]  
Published June 1, 2006

Christian C. Felder, Amy K. Dickason-Chesterfield, and Steven A. Moore

Cannabinoids Biology: The Search for New Therapeutic Targets
MI 2006 6: 149 10.1124/mi.6.3.6 [Summary] [Full Text] [PDF]  
Published June 1, 2006

Emily M. Jutkiewicz

The Antidepressant -like Effects of Delta-Opioid Receptor Agonists
MI 2006 6: 162 10.1124/mi.6.3.7 [Summary] [Full Text] [PDF]  
Published June 1, 2006

Timothy A. Esbenshade, Gerard B. Fox, and Marlon D. Cowart

Histamine H₃ Receptor Antagonists: Preclinical Promise for Treating Obesity and Cognitive Disorders
MI 2006 6: 77 10.1124/mi.6.2.5 [Summary] [Full Text] [PDF]  
Published April 1, 2006

Donna W. Lee, Julie K Andersen, and Deepinder Kaur

Iron Dysregulation and Neurodegeneration: The Molecular Connection
MI 2006 6: 89 10.1124/mi.6.2.6 [Summary] [Full Text] [PDF]  
Published April 1, 2006

Bi-Sen Ding, Thomas Dziubla, Vladimir V. Shuvaev, Silvia Muro, and Vladimir R. Muzykantov

Advanced Drug Delivery Systems That Target The Vascular Endothelium
MI 2006 6: 98 10.1124/mi.6.2.7 [Summary] [Full Text] [PDF]  
Published April 1, 2006

Sue Piper Duckles, Diana N. Krause, Christopher Stirone, and Vincent Procaccio

Estrogen and Mitochondria: A New Paradigm for Vascular Protection?
MI 2006 6: 26 10.1124/mi.6.1.6 [Summary] [Full Text] [PDF]  
Published February 1, 2006

Dipak K. Das and Nilanjana Maulik

Resveratrol in Cardioprotection: A Therapeutic Promise of Alternative Medicine
MI 2006 6: 36 10.1124/mi.6.1.7 [Summary] [Full Text] [PDF]  
Published February 1, 2006

Julie M. Hall and Donald P. McDonnell

Coregulators in Nuclear Estrogen Receptor Action: From Concept to Therapeutic Targeting
MI 2005 5: 343 10.1124/mi.5.6.7 [Summary] [Full Text] [PDF]  
Published December 1, 2005

Nadia F. Lamour and Charles E. Chalfant

Ceramide-1-phosphate: The "missing" link in eicosanoid biosynthesis and inflammation
MI 2005 5: 358 10.1124/mi.5.6.8 [Summary] [Full Text] [PDF]  
Published December 1, 2005

Paul A. McCarron, Shane A. Olwill, Waleed M.Y. Marouf, Richard J. Buick, Brian Walker, and Christopher J. Scott

Antibody Conjugates and Therapeutic Strategies
MI 2005 5: 368 10.1124/mi.5.6.9 [Summary] [Full Text] [PDF]  
Published December 1, 2005

Keith J. Miller

SEROTONIN 5-HT_2C RECEPTOR AGONISTS: POTENTIAL FOR THE TREATMENT OF OBESITY
MI 2005 5: 282 10.1124/mi.5.5.8 [Summary] [Full Text] [PDF]  
Published October 1, 2005

Alicia M. Celotto and Michael J. Palladino

Drosophila: A "Model" Model System To Study Neurodegeneration
MI 2005 5: 292 10.1124/mi.5.5.9 [Summary] [Full Text] [PDF]  
Published October 1, 2005

Stephen J. Peroutka

NEUROGENIC INFLAMMATION AND MIGRAINE: IMPLICATIONS FOR THE THERAPEUTICS
MI 2005 5: 304 10.1124/mi.5.5.10 [Summary] [Full Text] [PDF]  
Published October 1, 2005

Alessandro Vitale and Emanuela Pedrazzini

Recombinant Pharmaceuticals from Plants: The Plant Endomembrane System as Bioreactor
MI 2005 5: 216 10.1124/mi.5.4.5 [Summary] [Full Text] [PDF]  
Published August 1, 2005

Anthony P. Williams, Andrew R. Bateman, and Salim I. Khakoo

HANGING IN THE BALANCE: KIR and Their Role in Disease
MI 2005 5: 226 10.1124/mi.5.4.6 [Summary] [Full Text] [PDF]  
Published August 1, 2005

Janice M. Burke and Leonard M. Hjelmeland

MOSAICISM OF THE RETINAL PIGMENT EPITHELIUM: seeing the small picture
MI 2005 5: 241 10.1124/mi.5.4.7 [Summary] [Full Text] [PDF]  
Published August 1, 2005

Xuyang Peng, Billy Chen, Chee Chew Lim, and Douglas B. Sawyer

The Cardiotoxicology of Anthracycline Chemotherapeutics: TRANSLATING MOLECULAR MECHANISM INTO PREVENTATIVE MEDICINE
MI 2005 5: 163 10.1124/mi.5.3.6 [Summary] [Full Text] [PDF]  
Published June 1, 2005

Jiyun Chen, Juhyun Kim, and James T. Dalton

Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators
MI 2005 5: 173 10.1124/mi.5.3.7 [Summary] [Full Text] [PDF]  
Published June 1, 2005

Terrance D. Barrett, David J. Triggle, Michael J.A. Walker, and Donald H. Maurice

Mechanism of Tissue-Selective Drug Action in the Cardiovascular System
MI 2005 5: 84 10.1124/mi.5.2.6 [Summary] [Full Text] [PDF]  
Published April 1, 2005

Marc W. Fariss, Catherine B. Chan, Manisha Patel, Bennett Van Houten, and Sten Orrenius

ROLE of MITOCHONDRIA in TOXIC OXIDATIVE STRESS
MI 2005 5: 94 10.1124/mi.5.2.7 [Summary] [Full Text] [PDF]  
Published April 1, 2005

Harm J. Knot, Ismail Laher, Eric A. Sobie, Silvia Guatimosim, Leticia Gomez-Viquez, Hali Hartmann, Long-Sheng Song, W.J. Lederer, Wolfgang F. Graier, Roland Malli, Maud Frieden, and Ole H. Petersen

Twenty Years of Calcium Imaging: Cell Physiology to Dye For
MI 2005 5: 112 10.1124/mi.5.2.8 [Summary] [Full Text] [PDF]  
Published April 1, 2005

Steven R. Hursh, Chad M. Galuska, Gail Winger, and James H. Woods

The Economics of Drug Abuse: a Quantitative Assessment of Drug Demand
MI 2005 5: 20 10.1124/mi.5.1.6 [Summary] [Full Text] [PDF]  
Published February 1, 2005

John R. Traynor and Richard R. Neubig

REGULATORs OF G PROTEIN SIGNALING & DRUGS OF ABUSE
MI 2005 5: 30 10.1124/mi.5.1.7 [Summary] [Full Text] [PDF]  
Published February 1, 2005

Rainer K. Reinscheid, Yan-Ling Xu, and Olivier Civelli

Neuropeptide S: A New Player in the Modulation of Arousal and Anxiety
MI 2005 5: 42 10.1124/mi5.1.8 [Summary] [Full Text] [PDF]  
Published February 1, 2005

Lee E. Limbird

The Receptor Concept: A Continuing Evolution
MI 2004 4: 326 10.1124/mi.4.6.6 [Summary] [Full Text] [PDF] [Correction to doi]  
Published December 1, 2004

Kenneth A. Jacobson, Soo-Kyung Kim, Stefano Costanzi, and Zhan-Guo Gao

PURINE RECEPTORS: GPCR STRUCTURE AND AGONIST DESIGN
MI 2004 4: 337 10.1124/mi.4.6.7 [Summary] [Full Text] [PDF]  
Published December 1, 2004

Tammy M. Seasholtz and Joan Heller Brown

RHO SIGNALING in Vascular Diseases
MI 2004 4: 348 10.1124/mi.4.6.8 [Summary] [Full Text] [PDF]  
Published December 1, 2004

Jorge A. Quiroz, Todd D. Gould, and Husseini K. Manji

MOLECULAR EFFECTS of lithium
MI 2004 4: 259 10.1124/mi.4.5.6 [Summary] [Full Text] [PDF]  
Published October 1, 2004

C. Shun Wong and Albert J. Van der Kogel

MECHANISMS OF RADIATION INJURY TO THE CENTRAL NERVOUS SYSTEM: IMPLICATIONS FOR NEUROPROTECTION
MI 2004 4: 273 10.1124/mi.4.5.7 [Summary] [Full Text] [PDF]