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Molecular Interventions 9:70-74, (2009)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.9.2.5
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Viewpoint

Anti-HIV-1 Therapeutics: From FDA-approved Drugs to Hypothetical Future Targets

Catherine S. Adamson and Eric O. Freed

Virus-Cell Interaction Section, HIV Drug Resistance Program National Cancer Institute at Frederick, Maryland, 21702-1201

SUMMARY

More than twenty-five years after its discovery, HIV-1 remains one of the world’s most formidable and destructive pathogens. Several classes of anti-HIV-1 agents are currently in widespread clinical use in developed nations; however, viral resistance to these drugs limits their effectiveness in a growing number of patients. It is therefore imperative that novel drugs be developed. Recent advances in the fields of HIV-1 molecular virology and cell biology have revealed possible new targets for drug discovery. The current status of antiretroviral therapy and some of the promising new targets against which novel antiviral agents could be developed are discussed.






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Copyright © 2009 by the American Society for Pharmacology and Experimental Therapeutics.