HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by van Rijn, R. M. Articles by Whistler, J. L. Search for Related Content PubMed PubMed Citation Articles by van Rijn, R. M. Articles by Whistler, J. L.

The Only Way Is Up: Preventing Opioid Tolerance by Promoting Cell Surface Expression of MOR-DOR Heterodimers?

Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, California

SUMMARY

The development of morphine tolerance is a complicated process likely involving many different factors. Both µ (MOR) and (DOR) opi-oid receptors are known to influence morphine tolerance. Significantly, the role of both receptors appears to change during the acquisition of tolerance, and for both these receptors, regulated receptor trafficking may influence these changes. Morphine does not induce substantial endocytosis and recycling of MORs but appears to increase surface expression of DOR, which, under many conditions, is not efficiently transported to the cell surface. A recent report demonstrates that members of the family of Receptor Transporter Proteins increase surface expression of MOR-DOR heterodimers. The implications of these findings with regard to morphine tolerance are discussed.

This article has been cited by other articles:

				M. A. Simmons Let's Go Rafting: Ligand Functional Selectivity May Depend on Membrane Structure Mol. Interv., December 1, 2008; 8(6): 281 - 283. [Abstract] [Full Text] [PDF]