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Molecular Interventions 6:257-265, (2006)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.6.5.7
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Review

Salvinorin A

From Natural Product to Human Therapeutics

Timothy A. Vortherms1 and Bryan L. Roth1,2

1 Department of Pharmacology, School of Medicine and
2 Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, and National Institute of Mental Health Psychoactive Drug Screening Program, Chapel Hill, NC 27599


Formula

The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum has been increasingly used recreationally. The neoclerodane diterpene salvinorin A is the active component of S. divinorum, and recently, the {kappa} opioid receptor (KOR) has been identified, in vitro and in vivo, as its molecular target. The discovery of KOR as the molecular target of salvinorin A has opened up many opportunities for drug discovery and drug development for a number of psychiatric and non-psychiatric disorders.




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