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COX-2 in Inflammation and Resolution

¹ Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Charterhouse Square, London EC1M6BQ
² Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, 5 University Street, University College London, London WC1E 6JJ

Aspirin and the other NSAIDs have popularized the notion of inhibiting prostaglandins as a common anti-inflammatory strategy based on the erroneous premise that all eicosanoids are, within the context of inflammation, generally detrimental. However, our fascination with aspirin and the emergence of COX-2 has shown a more affable side to lipid mediators based on our increasing interest in the endogenous control of acute inflammation and in factors that mediate its resolution. Epilipoxins, for instance, are produced from aspirin’s acetylation of COX-2 and together with Resolvins and COX-2–derived prostaglandins of the D₂ and J₂ series represent an increasingly important family of immunoregulatory lipid mediators with strong implications for disease control and drug discovery.

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