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Molecular Interventions 6:89-97, (2006)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.6.2.6
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Review

Iron Dysregulation and Neurodegeneration: The Molecular Connection

Donna W. Lee, Julie K Andersen and Deepinder Kaur

Buck Institute for Age Research, Novato, California 94945


Formula

Iron is essential for many biological processes however excess concentrations can be harmful to many tissues. Its amounts must therefore be carefully regulated in all cells of the body including those in the brain. Increased amounts of iron have been reported in many neurodegenerative disorders. Whether this increased iron contributes to neurodegeneration has been considered controversial. In this review, we discuss some recently identified anomalies in proteins linked with iron metabolism which signify a critical role for iron dysregulation in neurodegeneration.




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Copyright © 2006 by the American Society for Pharmacology and Experimental Therapeutics.