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sorLA: Sorting Out APP

Center for Basic Neuroscience and Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390

SUMMARY

The accumulation of amyloid-ß peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-ß peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-ß peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.

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