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Molecular Interventions 5:340-342, (2005)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.5.6.6
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Increased Expression and Function of Vascular {alpha}1D-Adrenoceptors May Mediate The Prohypertensive Effects Of Angiotensin II

Rafael Villalobos-Molina and Maximiliano Ibarra

Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de Mexico, Tlalnepantla, México.

SUMMARY

The peptide Angiotensin II (Ang II), part of the renin-angiotensin system (RAS), participates in the control of systemic arterial pressure. Ang II participates in increasing smooth muscle tone, and its positive effects on smooth muscle cell DNA synthesis are inhibited by treatment with prazosin, an {alpha}1-adrenoceptor agonist. Ang II also induces the expression of {alpha}1-adrenoceptor, especially the {alpha}1D subtype. Other findings suggest that the molecular signals activated by Ang II and by {alpha}1D-adrenoceptor might interweave, thus leading to the augmentation of smooth muscle tone and hypertension.




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Copyright © 2005 by the American Society for Pharmacology and Experimental Therapeutics.