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Molecular Interventions 5:335-337, (2005)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.5.6.4
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A Bacterial Sensory System that Activates Resistance to Innate Immune Defenses: Potential Targets for Antimicrobial Therapeutics

Igor E. Brodsky1 and John S. Gunn2

1 Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520,
2 Department of Molecular Virology, Immunology, and Medical Genetics and Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210

SUMMARY

Bacteria posses multiple two component regulatory systems consisting typically of a kinase and a transcription factor that, in concert, monitor the concentrations of particular extracellular factors and regulate specific gene expression accordingly. Salmonella possess PhoP-PhoQ, which are activated under conditions of suboptimal [Mg2+] and result in gene expression leading to greater stability of the outer membrane. New research identifies PhoQ as a receptor for sublethal concentrations of antimicrobial peptides (AMPs), adapting bacteria for survival. The development of AMPs that do not activate Phop-PhoQ, however, should proceed with great caution: AMPs are part of the host innate immune response and bacterial resistance to newly developed AMPs could possibly lead to intractable infection in immunocompetent hosts.




This article has been cited by other articles:


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T. Miyashiro and M. Goulian
Stimulus-dependent differential regulation in the Escherichia coli PhoQ PhoP system
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[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
M. Li, Y. Lai, A. E. Villaruz, D. J. Cha, D. E. Sturdevant, and M. Otto
Gram-positive three-component antimicrobial peptide-sensing system
PNAS, May 29, 2007; 104(22): 9469 - 9474.
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