MI Sign Up for eTOC Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Molecular Interventions 5:292-303, (2005)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.5.5.9
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Celotto, A. M.
Right arrow Articles by Palladino, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Celotto, A. M.
Right arrow Articles by Palladino, M. J.
Review

Drosophila

A "Model" Model System To Study Neurodegeneration

Alicia M. Celotto and Michael J. Palladino

Department of Pharmacology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261


{TitleArt_Palladino}

The fruit fly, Drosophila melanogaster, is a powerful model genetic organism that has been used since the turn of the previous century in the study of complex biological problems. In the last decade, numerous researchers have focused their attention on understanding neurodegenerative diseases by utilizing this model system. Numerous Drosophila mutants have been isolated that profoundly affect neural viability and integrity of the nervous system with age. Additionally, many transgenic strains have been developed as models of human disease conditions. We review the existing Drosophila neurodegenerative mutants and transgenic disease models, and discuss the role of the fruit fly in therapeutic development for neurodegenerative diseases.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. E. Phillips, E. A. Woodruff III, P. Liang, M. Patten, and K. Broadie
Neuronal Loss of Drosophila NPC1a Causes Cholesterol Aggregation and Age-Progressive Neurodegeneration
J. Neurosci., June 25, 2008; 28(26): 6569 - 6582.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. Fergestad, L. Olson, K. P. Patel, R. Miller, M. J. Palladino, and B. Ganetzky
Neuropathology in Drosophila Mutants With Increased Seizure Susceptibility
Genetics, February 1, 2008; 178(2): 947 - 956.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. M. Celotto, A. C. Frank, J. L. Seigle, and M. J. Palladino
Drosophila Model of Human Inherited Triosephosphate Isomerase Deficiency Glycolytic Enzymopathy
Genetics, November 1, 2006; 174(3): 1237 - 1246.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPET Journals Pharmacological Reviews Drug Metabolism and Disposition
Molecular Interventions Molecular Pharmacology J Pharmacology and Exp Therapeutics
Copyright © 2005 by the American Society for Pharmacology and Experimental Therapeutics.