MI Visit the ASPET Website
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Molecular Interventions 5:158-161, (2005)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.5.3.5
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hasbi, A.
Right arrow Articles by George, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hasbi, A.
Right arrow Articles by George, S. R.

Viewpoint

A G Protein–Coupled Receptor For Estrogen: The End Of The Search?

Ahmed Hasbi1, Brian F. O’Dowd1,2 and Susan R. George1,2,3

1 Departments of Pharmacology and
2 Medicine,
3 University of Toronto and the Center for Addiction and Mental Health, Toronto, Ontario, Canada

SUMMARY

The effects of estrogen on responsive cells and organismic development have long been known and well documented. Estrogen binds to the estrogen receptor, a dimer of the complex translocates to the nucleus, binds specific DNA elements and regulates the transcription of particular genes, a process that takes some time to achieve. One of the curious findings of intense estrogen research—that some estrogen-dependent effects appear to occur immediately—has led to the conclusion that quick responses are mediated by an estrogen binding protein(s) in the cytoplasm or located at the plasma membrane. Hasbi et al. chart the course through which several characterized estrogen binding proteins (not necessarily sharing sequence similarity beyond the estrogen binding domain) were discovered, including most notably, the orphan G protein–coupled receptor GPR30. And what is to be made of differing accounts of GPR30’s intracellular whereabouts?




This article has been cited by other articles:


Home page
 EndocrinologyHome page
L. Albanito, D. Sisci, S. Aquila, E. Brunelli, A. Vivacqua, A. Madeo, R. Lappano, D. P. Pandey, D. Picard, L. Mauro, et al.
Epidermal Growth Factor Induces G Protein-Coupled Receptor 30 Expression in Estrogen Receptor-Negative Breast Cancer Cells
Endocrinology, August 1, 2008; 149(8): 3799 - 3808.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
V. M. Miller and S. P. Duckles
Vascular Actions of Estrogens: Functional Implications
Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. D. Feldman and R. Gros
Choreographing the Rapid Vascular Effects of Estrogen: Sorting Out the Partners and the Steps
Hypertension, June 1, 2007; 49(6): 1222 - 1224.
[Full Text] [PDF]

Home page
 HypertensionHome page
M. R. Meyer, E. Haas, and M. Barton
Gender Differences of Cardiovascular Disease: New Perspectives for Estrogen Receptor Signaling
Hypertension, June 1, 2006; 47(6): 1019 - 1026.
[Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. D'Astous, P. Mendez, M. Morissette, L. M. Garcia-Segura, and T. Di Paolo
Implication of the Phosphatidylinositol-3 Kinase/Protein Kinase B Signaling Pathway in the Neuroprotective Effect of Estradiol in the Striatum of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice
Mol. Pharmacol., April 1, 2006; 69(4): 1492 - 1498.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPET Journals Pharmacological Reviews Drug Metabolism and Disposition
Molecular Interventions Molecular Pharmacology J Pharmacology and Exp Therapeutics
Copyright © 2005 by the American Society for Pharmacology and Experimental Therapeutics.