|
|
||||||||
1 Department of Pharmacology & Therapeutics and Division of Cardiology College of Medicine, University of Florida, Gainesville, FL
2 Department of Pharmacology and Therepeutics, University of British Columbia, Vancouver, BC
3 Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD
4 Institue of Molecular Biology & Biochemistry, Medical University of Graz, Austria
5 Department of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland
6 The Physiological Laboratory, University of Liverpool, Liverpool, UK

The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca2+ in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca2+ signaling is accomplished. In excitable cells, the coordination of changing Ca2+ concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca2+ signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes.
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ASPET Journals | Pharmacological Reviews | Drug Metabolism and Disposition |
| Molecular Interventions | Molecular Pharmacology | J Pharmacology and Exp Therapeutics |