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The Ileocyte Basolateral Organic Solute Transporter (OST–OSTß) Complex: Finding The Missing Link in Enterohepatic Circulation

¹ Virginia Commonwealth University School of Pharmacy, Department of Pharmaceutics, Richmond, VA 23298-0533;
² University of Kentucky Graduate Center for Toxicology, Lexington, KY 40536-0305

SUMMARY

Many drugs are removed from the body through a multistep process that includes covalent conjugation, transport into the bile, and excretion. Bile acids are transported across the ileocyte apical (brush border) membrane by the apical sodium-dependent bile-acid transporter (Asbt), but the identity of the primary transporter responsible for moving bile acids across the basolateral membrane of the ileocyte has remained a mystery, although not for a lack of protein pretenders to the throne. Recent insights from transcriptional profiling studies of wild-type and Asbt-deficient mice indicate that a complex formed by the organic solute carrier proteins and ß (Ost and Ostß) is the primary transporter for basolateral bile acid transport.

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