MI Sign Up for eTOC Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Molecular Interventions 4:326-336, (2004)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.4.6.6
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correction to doi
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Limbird, L. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Limbird, L. E.
Review

The Receptor Concept: A Continuing Evolution

Lee E. Limbird

Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University School of Medicine, and Vanderbilt Kennedy Center for Research on Human Development, Nashville, Tennessee 37232


{Limb_titleart}

This review briefly summarizes the development of the receptor concept, the identification of receptors based first on biological response data and subsequently on radioligand binding properties, and the biological and physiological understandings that these approaches have made possible. The development of receptor characterization began with receptors that ultimately were discovered to mediate response by coupling to G-binding proteins, also known as G protein–coupled receptors (GPCRs). Consequently, many if not all of the examples in this overview will describe studies characterizing GPCRs in general, and adrenergic receptors in particular. The purpose of this review, however, is not a detailed chronological account of a huge literature, but rather an overview of the fundamental questions posed and answered by these studies.




This article has been cited by other articles:


Home page
 Mol. Interv.Home page
P. E. Q. de Oliveira, R. J. Tomko Jr., and J. S. Lazo
Is a Step Backwards in S-Phase-Targeted Chemotherapy a Step Forward?
Mol. Interv., June 1, 2008; 8(3): 137 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Stanisavljevic, T. Ignjatovic, P. A. Deddish, V. Brovkovych, K. Zhang, E. G. Erdos, and R. A. Skidgel
Angiotensin I-Converting Enzyme Inhibitors Block Protein Kinase C{epsilon} by Activating Bradykinin B1 Receptors in Human Endothelial Cells
J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1153 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
T. D. Barrett, D. J. Triggle, M. J.A. Walker, and D. H. Maurice
Mechanism of Tissue-Selective Drug Action in the Cardiovascular System
Mol. Interv., April 1, 2005; 5(2): 84 - 93.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPET Journals Pharmacological Reviews Drug Metabolism and Disposition
Molecular Interventions Molecular Pharmacology J Pharmacology and Exp Therapeutics
Copyright © 2004 by the American Society for Pharmacology and Experimental Therapeutics.