MI Visit the ASPET Website
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Molecular Interventions 4:86-96, (2004)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.4.2.6
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ivanova, P. T.
Right arrow Articles by Brown, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ivanova, P. T.
Right arrow Articles by Brown, H. A.
Review

LIPID Arrays: New Tools in the Understanding of Membrane Dynamics and Lipid Signaling

Pavlina T. Ivanova, Stephen B. Milne, Jeffrey S. Forrester and H. Alex Brown

Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232

Correspondence: Address correspondence to HAB. E-mail alex.brown{at}vanderbilt.edu; fax 615-343-6532.


Phospholipids are the structural building blocks of the membrane bilayer, which retains and regulates intra-cellular content. In addition to creating a protective barrier around the cell, lipids modulate membrane trafficking and are themselves precursors of important intracellular signaling molecules. Identification and quantification of these molecular species is essential for a more complete understanding of cell signaling pathways, and more reliable and sensitive methods are needed for determining membrane phospholipid content. Recent improvements in electrospray ionization mass spectrometry have made possible the direct identification of more than 400 phospholipid species from biological extracts of a single cell type. Changes in the cellular concentration of diverse lipids can be determined by analysis of the mass spectra by statistical algorithms. In the future, lipid arrays will be integrated with other high-throughput profiling technologies, and computational lipidomics will expand our understanding of the molecular basis of cellular processes and diseases.




This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
G. R. Kinsey, J. L. Blum, M. D. Covington, B. S. Cummings, J. McHowat, and R. G. Schnellmann
Decreased iPLA2{gamma} expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis
J. Lipid Res., July 1, 2008; 49(7): 1477 - 1487.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. Gomez-Cambronero, M. Di Fulvio, and K. Knapek
Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis
J. Leukoc. Biol., August 1, 2007; 82(2): 272 - 281.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. D. Watson
Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Lipidomics: a global approach to lipid analysis in biological systems
J. Lipid Res., October 1, 2006; 47(10): 2101 - 2111.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
E. Fahy, S. Subramaniam, H. A. Brown, C. K. Glass, A. H. Merrill Jr., R. C. Murphy, C. R. H. Raetz, D. W. Russell, Y. Seyama, W. Shaw, et al.
A comprehensive classification system for lipids
J. Lipid Res., May 1, 2005; 46(5): 839 - 862.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPET Journals Pharmacological Reviews Drug Metabolism and Disposition
Molecular Interventions Molecular Pharmacology J Pharmacology and Exp Therapeutics
Copyright © 2004 by the American Society for Pharmacology and Experimental Therapeutics.