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Molecular Interventions 4:83-85, (2004)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.4.2.5
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Viewpoint

Dedifferentiation? What’s next?

Sungwoo Kim1, Gus R. Rosania2 and Young-Tae Chang3

1 Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037;
2 Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, MI 48109;
3 Department of Chemistry, New York University, NY, NY 10003

SUMMARY

Not so fast! Several things need to be considered before we conclude that Chen et al. have a dedifferentiating agent on their hands. The verification of small molecules as tissue- or cell-type dedifferentiating agents will require greatly sophisticated techniques and the identification of the direct molecular targets of said small molecules. By knowing what pitfalls to avoid, intelligent small-molecule design and testing may proceed more expediently.


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MI 2004 4: 127. [Full Text]  





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Copyright © 2004 by the American Society for Pharmacology and Experimental Therapeutics.