| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Pediatrics, Division of Respiratory Medicine and
2 Division of Critical Care Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908 USA
S-Nitrosylated proteins form when a cysteine thiol reacts with nitric oxide (NO) in the presence of an electron acceptor to form an S-NO bond. Under physiological conditions, this posttranslational modification affects the function a wide array of cell proteins, ranging from ion channels to nuclear regulatory proteins. Recent evidence suggests that 1) S-nitrosylated proteins can be synthesized by exposure of specific redox-active motifs to NO, through transnitrosation/transfer reactions, or through metalloprotein-catalyzed reactions; 2) S-nitrosothiols can be sequestered in membranes, lipophilic protein folds, or in vesicles to preserve their activity; and 3) S-nitrosothiols can be degraded by a number of enzymes systems. These recent insights regarding the bioactivities, molecular signaling pathways, and metabolism of endogenous S-nitrosothiols have suggested several new therapies for disease ranging from cystic fibrosis to pulmonary hypertension.
This article has been cited by other articles:
|
|
 |
|
  S. W. Rabkin and M. Y. C. Tsang The action of nitric oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death Exp Physiol, July 1, 2008; 93(7): 834 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhu, S. Li, Z. M. Marshall, and A. R. Whorton A cystine-cysteine shuttle mediated by xCT facilitates cellular responses to S-nitrosoalbumin Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1012 - C1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Carver, B. Gaston, K. deRonde, and L. A. Palmer Akt-Mediated Activation of HIF-1 in Pulmonary Vascular Endothelial Cells by S-Nitrosoglutathione Am. J. Respir. Cell Mol. Biol., September 1, 2007; 37(3): 255 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Derakhshan, G. Hao, and S. S. Gross Balancing reactivity against selectivity: The evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide Cardiovasc Res, July 15, 2007; 75(2): 210 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Raines, M. G. Bonini, and S. L. Campbell Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases Cardiovasc Res, July 15, 2007; 75(2): 229 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. MacRitchie, A. A. Gardner, S. M. Prescott, and D. M. Stafforini Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation FASEB J, April 1, 2007; 21(4): 1164 - 1176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Li and A. R. Whorton Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1263 - C1271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Brault, F. Gobeil Jr., A. Fortier, J.-C. Honore, J.-S. Joyal, P. S. Sapieha, A. Kooli, E. Martin, P. Hardy, A. Ribeiro-da-Silva, et al. Lysophosphatidic acid induces endothelial cell death by modulating the redox environment Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1174 - R1183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, M. Wittner, H. Bouamar, P. Jarrier, W. Vainchenker, and F. Louache Identification of CXCR4 as a New Nitric Oxide-Regulated Gene in Human CD34+ Cells Stem Cells, January 1, 2007; 25(1): 211 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. LoPachin and D. S. Barber Synaptic Cysteine Sulfhydryl Groups as Targets of Electrophilic Neurotoxicants Toxicol. Sci., December 1, 2006; 94(2): 240 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Zaman, S. Carraro, J. Doherty, E. M. Henderson, E. Lendermon, L. Liu, G. Verghese, M. Zigler, M. Ross, E. Park, et al. S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells Mol. Pharmacol., October 1, 2006; 70(4): 1435 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Carraro, J. Doherty, K. Zaman, I. Gainov, R. Turner, J. Vaughan, J. F. Hunt, J. Marquez, and B. Gaston S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L827 - L832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lindermayr, G. Saalbach, G. Bahnweg, and J. Durner Differential Inhibition of Arabidopsis Methionine Adenosyltransferases by Protein S-Nitrosylation J. Biol. Chem., February 17, 2006; 281(7): 4285 - 4291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hao, B. Derakhshan, L. Shi, F. Campagne, and S. S. Gross SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures PNAS, January 24, 2006; 103(4): 1012 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sugita, M. Fujimoto, T. Yasukawa, N. Shimizu, M. Sugita, S. Yasuhara, J. A. J. Martyn, and M. Kaneki Inducible Nitric-oxide Synthase and NO Donor Induce Insulin Receptor Substrate-1 Degradation in Skeletal Muscle Cells J. Biol. Chem., April 8, 2005; 280(14): 14203 - 14211. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ASPET Journals | Pharmacological Reviews | Drug Metabolism and Disposition |
| Molecular Interventions | Molecular Pharmacology | J Pharmacology and Exp Therapeutics |
