MI Sign Up for eTOC Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bayliss, D. A.
Right arrow Articles by Talley, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bayliss, D. A.
Right arrow Articles by Talley, E. M.
Review

The TASK Family: Two-Pore Domain Background K+ Channels

Douglas A. Bayliss1,2, Jay E. Sirois2 and Edmund M. Talley1

1 Departments of Pharmacology and
2 Anesthesiology, School of Medicine, University of Virginia, Charlottesville, VA

Correspondence: Address correspondence to DAB. Email: dab3y{at}virginia.edu; fax 434-982-3878.


Formula

The recent identification of a distinct family of genes encoding two-pore domain potassium channels that generate background, or leak, K+ currents has permitted the analysis of the molecular underpinnings of these heretofore poorly understood currents. In the case of the TASK subfamily of channels, particularly TASK-1 (KCNK3) and TASK-3 (KCNK9), detailed characterization of cloned (and heterologously expressed) channels has revealed sets of unique properties that, together with information regarding sites of expression, have permitted identification of their native counterparts. This analysis has demonstrated that native TASK-like channels are subject to multiple forms of modulation (e.g., by protons, volatile anesthetics, oxygen tension, and receptor-mediated signaling pathways), which serve as a basis for participation in a number of physiological mechanisms. In this review, we describe the salient features of cloned TASK channels, present evidence for their functional expression in a number of tissues (e.g., brain, heart, and adrenal gland), and discuss possible roles for these channels in pH-dependent physiological processes (e.g., breathing and arousal) and in the clinical actions of inhalation anesthetics.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Trapp, M. Isabel Aller, W. Wisden, and A. V. Gourine
A Role for TASK-1 (KCNK3) Channels in the Chemosensory Control of Breathing
J. Neurosci., August 27, 2008; 28(35): 8844 - 8850.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Heitzmann and R. Warth
Physiology and Pathophysiology of Potassium Channels in Gastrointestinal Epithelia
Physiol Rev, July 1, 2008; 88(3): 1119 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Koizumi, C. G. Wilson, S. Wong, T. Yamanishi, N. Koshiya, and J. C. Smith
Functional Imaging, Spatial Reconstruction, and Biophysical Analysis of a Respiratory Motor Circuit Isolated In Vitro
J. Neurosci., March 5, 2008; 28(10): 2353 - 2365.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Koizumi and J. C. Smith
Persistent Na+ and K+-Dominated Leak Currents Contribute to Respiratory Rhythm Generation in the Pre-Botzinger Complex In Vitro
J. Neurosci., February 13, 2008; 28(7): 1773 - 1785.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Davies, C. Hu, N. A. Guagliardo, N. Sen, X. Chen, E. M. Talley, R. M. Carey, D. A. Bayliss, and P. Q. Barrett
TASK channel deletion in mice causes primary hyperaldosteronism
PNAS, February 12, 2008; 105(6): 2203 - 2208.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. K. Mulkey, E. M. Talley, R. L. Stornetta, A. R. Siegel, G. H. West, X. Chen, N. Sen, A. M. Mistry, P. G. Guyenet, and D. A. Bayliss
TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity
J. Neurosci., December 19, 2007; 27(51): 14049 - 14058.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Dobler, A. Springauf, S. Tovornik, M. Weber, A. Schmitt, R. Sedlmeier, E. Wischmeyer, and F. Doring
TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones
J. Physiol., December 15, 2007; 585(3): 867 - 879.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A.-M. Linden, C. Sandu, M. I. Aller, O. Y. Vekovischeva, P. H. Rosenberg, W. Wisden, and E. R. Korpi
TASK-3 Knockout Mice Exhibit Exaggerated Nocturnal Activity, Impairments in Cognitive Functions, and Reduced Sensitivity to Inhalation Anesthetics
J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 924 - 934.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. R. Lopez-Lopez and M. T. Perez-Garcia
An ASIC Channel for Acid Chemotransduction
Circ. Res., November 9, 2007; 101(10): 965 - 967.
[Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P.-Y. Deng, S. K. S. Poudel, L. Rojanathammanee, J. E. Porter, and S. Lei
Serotonin Inhibits Neuronal Excitability by Activating Two-Pore Domain K+ Channels in the Entorhinal Cortex
Mol. Pharmacol., July 1, 2007; 72(1): 208 - 218.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Putzke, K. Wemhoner, F. B. Sachse, S. Rinne, G. Schlichthorl, X. T. Li, L. Jae, I. Eckhardt, E. Wischmeyer, H. Wulf, et al.
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle
Cardiovasc Res, July 1, 2007; 75(1): 59 - 68.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. H. Williams, L. T. Jensen, A. Verkhratsky, L. Fugger, and D. Burdakov
Control of hypothalamic orexin neurons by acid and CO2
PNAS, June 19, 2007; 104(25): 10685 - 10690.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Gonzalez-Forero, F. Portillo, L. Gomez, F. Montero, S. Kasparov, and B. Moreno-Lopez
Inhibition of Resting Potassium Conductances by Long-Term Activation of the NO/cGMP/Protein Kinase G Pathway: A New Mechanism Regulating Neuronal Excitability
J. Neurosci., June 6, 2007; 27(23): 6302 - 6312.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. J. Margolis and P. B. Detwiler
Different Mechanisms Generate Maintained Activity in ON and OFF Retinal Ganglion Cells
J. Neurosci., May 30, 2007; 27(22): 5994 - 6005.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P.-Y. Deng, J. E. Porter, H.-S. Shin, and S. Lei
Thyrotropin-releasing hormone increases GABA release in rat hippocampus
J. Physiol., December 1, 2006; 577(2): 497 - 511.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. L. Torborg, A. P. Berg, B. W. Jeffries, D. A. Bayliss, and C. J. McBain
TASK-like conductances are present within hippocampal CA1 stratum oriens interneuron subpopulations.
J. Neurosci., July 12, 2006; 26(28): 7362 - 7367.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A.-M. Linden, M. I. Aller, E. Leppa, O. Vekovischeva, T. Aitta-aho, E. L. Veale, A. Mathie, P. Rosenberg, W. Wisden, and E. R. Korpi
The in Vivo Contributions of TASK-1-Containing Channels to the Actions of Inhalation Anesthetics, the {alpha}2 Adrenergic Sedative Dexmedetomidine, and Cannabinoid Agonists
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 615 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Musset, S. G. Meuth, G. X. Liu, C. Derst, S. Wegner, H.-C. Pape, T. Budde, R. Preisig-Muller, and J. Daut
Effects of divalent cations and spermine on the K+ channel TASK-3 and on the outward current in thalamic neurons
J. Physiol., May 1, 2006; 572(3): 639 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. G. Meuth, M. I. Aller, T. Munsch, T. Schuhmacher, T. Seidenbecher, P. Meuth, C. Kleinschnitz, H.-C. Pape, H. Wiendl, W. Wisden, et al.
The Contribution of TWIK-Related Acid-Sensitive K+-Containing Channels to the Function of Dorsal Lateral Geniculate Thalamocortical Relay Neurons
Mol. Pharmacol., April 1, 2006; 69(4): 1468 - 1476.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
G. Czirjak and P. Enyedi
Zinc and Mercuric Ions Distinguish TRESK from the Other Two-Pore-Domain K+ Channels
Mol. Pharmacol., March 1, 2006; 69(3): 1024 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. I. Aller, E. L. Veale, A.-M. Linden, C. Sandu, M. Schwaninger, L. J. Evans, E. R. Korpi, A. Mathie, W. Wisden, and S. G. Brickley
Modifying the Subunit Composition of TASK Channels Alters the Modulation of a Leak Conductance in Cerebellar Granule Neurons
J. Neurosci., December 7, 2005; 25(49): 11455 - 11467.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Besana, A. Barbuti, M. A. Tateyama, A. J. Symes, R. B. Robinson, and S. J. Feinmark
Activation of Protein Kinase C {epsilon} Inhibits the Two-pore Domain K+ Channel, TASK-1, Inducing Repolarization Abnormalities in Cardiac Ventricular Myocytes
J. Biol. Chem., August 6, 2004; 279(32): 33154 - 33160.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. P. Berg, E. M. Talley, J. P. Manger, and D. A. Bayliss
Motoneurons Express Heteromeric TWIK-Related Acid-Sensitive K+ (TASK) Channels Containing TASK-1 (KCNK3) and TASK-3 (KCNK9) Subunits
J. Neurosci., July 28, 2004; 24(30): 6693 - 6702.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPET Journals Pharmacological Reviews Drug Metabolism and Disposition
Molecular Interventions Molecular Pharmacology J Pharmacology and Exp Therapeutics
Copyright © 2003 by the American Society for Pharmacology and Experimental Therapeutics.