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Discovery of an Innate Cancer Resistance Gene?

Cancer Immunology Program Peter MacCallum Cancer Centre East Melbourne, 3002, Victoria, Australia

SUMMARY

Advances in cancer research have exploited the knowledge that mutations in proto-oncogenes and/or mutations in both alleles of tumor suppressor genes can bring about the cancer phenotype. Research originating from the opposite side of the coin—cancer-resistance genetics—has been less spectacular. Nonetheless, Cui et al. have observed one BALB/c mouse that did not bear tumors after receiving repeated injections of highly aggressive tumor cells. After breeding a colony of cancer-resistant mice from the resistant founder, the authors found that the trait was inherited in simple Mendelian dominant fashion, most likely under the control of a single locus. Intriguingly, this resistance trait disappears with age.

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