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Cancer Immunology Program Peter MacCallum Cancer Centre East Melbourne, 3002, Victoria, Australia
SUMMARY
Advances in cancer research have exploited the knowledge that mutations in proto-oncogenes and/or mutations in both alleles of tumor suppressor genes can bring about the cancer phenotype. Research originating from the opposite side of the coincancer-resistance geneticshas been less spectacular. Nonetheless, Cui et al. have observed one BALB/c mouse that did not bear tumors after receiving repeated injections of highly aggressive tumor cells. After breeding a colony of cancer-resistant mice from the resistant founder, the authors found that the trait was inherited in simple Mendelian dominant fashion, most likely under the control of a single locus. Intriguingly, this resistance trait disappears with age.
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