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Molecular Interventions 3:72-75 (2003)
© 2003 American Society of Pharmacology and Experimental Therapeutics

Viewpoint

Knockout Mouse Points to Second Form of Tryptophan Hydroxylase

Jeremy Veenstra-VanderWeele1 and Edwin H. Cook, Jr.1,2

1 Department of Psychiatry,
2 Departments of Pediatrics and Human Genetics; Committees on Clinical Pharmacology and Pharmacogenomics, Molecular Medicine, Genetics, The University of Chicago, Chicago, Illinois 60637

Correspondence: EHC ed{at}yoda.bsd.uchicago.edu; fax 773-834-0505.

SUMMARY

A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2. The presence of the gene was discovered when Tph 1–/–mice were found to express normal amounts of serotonin in brain, but not in the periphery. Additionally, Tph1–/– mice showed no observed behavioral differences from wild-type littermates. Veenstra-Vanderweele and Cook discuss the ramifications of these findings and what they might mean for designing drugs that target the expression and activity of TPH in differing tissues.


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Copyright © 2003 by the American Society for Pharmacology and Experimental Therapeutics.