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Molecular Interventions 2:424-427 (2002)
© 2002 American Society of Pharmacology and Experimental Therapeutics

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Cytokines in Heart Failure: Potential Interactions with Angiotensin II and Leptin

Bethany J. Holycross1 and M. Judith Radin2

1 Dorothy M. Davis Heart and Lung Research Institute and
2 Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210

SUMMARY

During the process of heart failure, the myocardium undergoes progressive remodeling. Local proinflammatory cytokines, such as tumor necrosis factor-{alpha}, exacerbate the process by promoting chronic inflammation in the heart. Recent evidence indicates that angiotensin II (AII) may participate upstream of and in concert with proinflammatory cytokines to enhance the expression of these cytokines, thus augmenting the remodeling process. Other growth factors, such as leptin, ameliorate the effects of AII and proinflammatory cytokines. Holycross and Radin discuss the antagonistic roles of cytokines in heart failure.




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