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Molecular Interventions 2:352-355 (2002)
© 2002 American Society of Pharmacology and Experimental Therapeutics

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Phospholipase C–{gamma}1: A Phospholipase and Guanine Nucleotide Exchange Factor

Zhixiang Wang1 and Michael F. Moran2

1 Department of Cell Biology and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
2 MDS Proteomics, 251 Attwell Drive, Toronto M9W 7H4, Canada

SUMMARY

Although phospholipase C-{gamma} (PLC-{gamma}) participates in cellular mitogenesis, evidence indicates that the catalytic activity of PLC-{gamma} (to hydrolyze certain phosphoinositides) is nonessential to the process. So how is it that PLC-{gamma} is necessary but its lipase activity is not? Recently published results from Snyder and colleagues describe the ability of PLC-{gamma} to facilitate guanine nucleotide exchange for the recently identified nucleus-localized GTPase PIKE, which acts to enhance the enzymatic activity of phosphatidylinositol 3'-kinase (PI3K). The authors contend that the SH3 domain, rather than the catalytic domain, of PLC-{gamma} is required for aiding PIKE, and furthermore, that the mitogenic activity of PLC-{gamma} depends not on its phospholipase activity, but rather on its interaction with PIKE. Wang and Moran examine the results and piece together a picture of how PLC-{gamma} cooperates with PIKE.




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[Abstract] [Full Text] [PDF]


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