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Molecular Interventions 2:286-289 (2002)
© 2002 American Society of Pharmacology and Experimental Therapeutics

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p53 Moves Into Control of Cell Morphology

Erik Sahai

Institute of Cancer Research, London SW3 6JB, United Kingdom

SUMMARY

Altered regulation of cell cycle, DNA repair, and apoptosis may not be the only ways that loss of p53 contributes to tumorigenesis. Roux and colleagues describe how the tumor suppressor protein p53 can regulate Cdc42-dependent (but neither RhoA- nor Rac-dependent) effects on cell morphology. The activation of p53 tends to inhibit the formation of Cdc42-dependent filopodia, pointing to a new way in which p53 exerts its tumor-suppressing activity: the prevention of cell spreading and motility. Sahai reviews these observations and discusses how insights gained from these studies will most likely lead to the identification of new targets for cancer therapy.






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ASPET Journals Pharmacological Reviews Drug Metabolism and Disposition
Molecular Interventions Molecular Pharmacology J Pharmacology and Exp Therapeutics
Copyright © 2002 by the American Society for Pharmacology and Experimental Therapeutics.