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Molecular Interventions 2:244-258 (2002)
© 2002 American Society of Pharmacology and Experimental Therapeutics

Review

Molecular Targets for Therapeutic Intervention after Spinal Cord Injury

Brian K. Kwon1,2, Jaimie F. Borisoff1 and Wolfram Tetzlaff1,3

1 International Collaboration on Repair Discoveries (ICORD)
2 Department of Orthopaedics,
3 Department of Surgery, University of British Columbia Vancouver, British Columbia, Canada V6T 1z4


In an effort to develop therapies for promoting neurological recovery after spinal cord injury, much work has been done to identify the cellular and molecular factors that control axonal regeneration within the injured central nervous system. This review summarizes the current understanding of a number of the elements within the spinal cord environment that inhibit axonal growth and outlines the factors that influence the neuron’s ability to regenerate its axon after injury. Recent insights in these areas have identified important molecular pathways that are potential targets for therapeutic intervention, raising hope for victims of spinal cord injury.




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