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Molecular Interventions 2:215-218 (2002)
© 2002 American Society of Pharmacology and Experimental Therapeutics

Viewpoint

Act Locally: New Ways of Regulating Voltage-Gated Ion Channels

Sharen E. McKay and Leonard K. Kaczmarek

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520

SUMMARY

A very recent publication by Aydar et al. describes how sigma receptors, which can bind psychoactive compounds and might regulate responses to stress, can interact with potassium receptors, and how (in the presence or absence of ligand) sigma receptors can differentially affect these potassium channels. MacKay and Kaczmarek discuss results that suggest a new mechanism of channel regulation and have implications for potassium channel research (including the possible development of clinical targets).






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Copyright © 2002 by the American Society for Pharmacology and Experimental Therapeutics.