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Emerging Roles for PKC Isoforms in Immune Cell Function

¹ The Molecular Biology Institute, University of California, Los Angeles, CA 90095-1752, USA, and
² Department of Immunology and
³ Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA

SUMMARY

Two publications by Mecklenbräuker et al. and Miyamoto et al. describe an essential role for protein kinase C (PKC) in the development of immune tolerance, and suggest that PKC also participates in mechanisms that prevent autoimmunity. Su, Guo, and Rawlings discuss these observations within the larger context of determining specific functions for individual isoforms of PKC in B and T lymphocytes, and the careful control these proteins exert in maintaining proper lymphocyte activation and tolerance.

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