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Emerging Roles of TACE as a Key Protease in ErbB Ligand Shedding

¹ Pacific Northwest Research Institute, Seattle, WA 98122, USA and
² Department of Pathology, Harborview Medical Center, University of Washington, Seattle, WA, 98104, USA

SUMMARY

Sunnarborg et al. have published how tumor necrosis factor- converting enzyme (TACE) can control the availability of transforming growth factor-—a natural ligand for epidermal growth factor receptors (EGFRs)—for EGFRs located at the cell surface. Dempsey, Garton, and Raines examine the ramifications of TACE-dependent proteolytic cleavage of membrane-bound ligands on paracrine, juxtacrine, and autocrine signaling.

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