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Molecular Interventions 2:132-134 (2002)
© 2002 American Society of Pharmacology and Experimental Therapeutics

Viewpoint

Pulse-Chase in the Light Microscope

Daniel Goodenough and Friso Postma

Department of Cell Biology and Department of Neurobiology Harvard Medical School, Boston, MA 02115, USA

SUMMARY

A recent publication by Gaietta et al. describes the real-time trafficking of connexin, and through the use of different fluors, researchers can discriminate between "older" and newly synthesized connexins. Goodenough and Postma discuss how the technique permits the visualization of dynamic building and degradation that occurs in subcellular compartments, and how the method can be used to analyze protein fates in real time.






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Copyright © 2002 by the American Society for Pharmacology and Experimental Therapeutics.