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Department of Pharmacology University of California Irvine Ca 92697
Correspondence: QYZ. E-mail qzhou{at}uci.edu; fax 949-824-4855.
Proteins that reside in the endoplasmic reticulum, such as the dopamine receptor-associated DRiP78 protein (shown in red) are being increasingly discovered as essential for the transport of G protein-coupled receptors through the Golgi apparatus (green) and to their destinations at the cell surface. [Reprinted with permission from Nature Cell Biology.]
Intracellular accessory proteins can be critical for G protein–coupled receptor (GPCR) biogenesis, including aspects of GPCR trafficking. Recent discoveries include the identification of multiple membrane-associated proteins that dictate not only the intracellular sequestration and/or transport of GPCRs, but also modulate—quite dramatically—GPCR ligand specificity subsequent to delivery to the cell surface. These exciting discoveries have shifted earlier paradigms of GPCR functionality.
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